Urotensin II (114-124), human TFA ( —— )

产品货号. M30114 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Urotensin II (114-124), human TFA
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
产品描述

Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.(In Vitro):Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6).(In Vivo):Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction.
同义词

——
通路

Others
靶点

Other Targets
受体

GPR14
研究领域

——
适应症

——

CAS Number

——
分子量

1502.6
分子式

C66H86F3N13O20S2
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

Sequence:Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: Cys5-Cys7)

Ames RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6.

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